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. Author manuscript; available in PMC: 2011 Jun 9.
Published in final edited form as: Cell Metab. 2010 Jun 9;11(6):453–465. doi: 10.1016/j.cmet.2010.05.001

Figure 2. TOR pathway, a conserved mediator of lifespan extension in multiple species.

Figure 2

The diagram represents the genetic interactions in the TOR signaling network that execute lifespan extension in yeast, worms, flies and mice. The diagram summarizes the lifespan data for genes in the TOR signaling pathway or those that demonstrate a genetic interaction with mutants in the TOR pathway. The shaded area refers to components of the TOR pathway that show conserved effects on lifespan extension in different species. See main text for details.