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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Neuropharmacology. 2004 May;46(6):856–864. doi: 10.1016/j.neuropharm.2003.11.029

Fig. 1.

Fig. 1

Patterns of hippocampal epileptiform activity with increasing doses of PS. Each panel represents a continuous EEG recording from a ventral hippocampal electrode (contralateral to the injection cannula) during the first 30 min after the PS infusion was completed. (A) A 100 nM dose of PS produces isolated discharges followed by the long periods of relatively normal EEG. (B) Higher dose of PS (2 µmol) produces recurrent a pattern of closely spaced discharges with short periods of low amplitude epileptiform activity between paroxysms. (C) Infusion of a high doses of PS (4.0 µmol) resulted in continuous, high amplitude discharges with some variation in the frequency of epileptiform bursts.