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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Neuropharmacology. 2004 May;46(6):856–864. doi: 10.1016/j.neuropharm.2003.11.029

Fig. 2.

Fig. 2

Relationship between the dose of PS and the appearance of discrete seizures and SE. The abscissa shows the dose of PS infused into the hippocampus, and the ordinate shows the percent fraction of animals exhibiting either discrete seizures (squares) or SE (triangles). The percent fraction of animals that exhibited discrete seizures or SE increased as increasing doses of PS were infused into the hippocampus. Lines represent the best fit to a sigmoidal function. The ED50 for the appearance of SE was 2.7 µM which was significantly higher than that for the production of discrete seizures, 68 nM (68 nM (N = 4,5,4,4,6,4,4,4 for 4.0, 2.0, 1.0 µmol, 300, 30, 3.0, 1.0, 0.3 nmol, respectively).