Fig. 3.
Increasing doses of PS resulted in more intense behavioral seizures. The dose of PS infused is displayed on the abscissa while the BSS is shown on the ordinate. The BSS 1–5 were according to Racine criteria (see Materials and methods) with an additional score of 6 for the most severe behavioral seizure consisting of wild running. Doses of PS associated with the production of SE seem to produce a large jump in the severity of behavioral seizures. There was a significant effect of the dose of PS on BSS (p≤ 0.001, Kruskal–Wallis ANOVA on ranks: N= 4,5,4,4,6,4,4,4 for 4.0, 2.0, 1.0 µmol, 300, 30, 3.0, 1.0, 0.3 nmol, respectively).
