Table 2.
ESCRT complexes and deubiquitinating enzyme homologues in Sch. pombe
| Complex | Homologue* | Sch. pombe | E-value† |
|---|---|---|---|
| Vps27/Hse1 | VPS27 | sst4/vps27+/SPAC19A8.05 | 7.8e–61 |
| HSE1 | hse1+/SPBC1734.08 | 6.3e–59 | |
| ESCRT-I | VPS23/STP22 | sst6+/SPAC11H11.01 | 2.5e–07 |
| VPS28 | vps28+/SPAC1B3.07 | 1.3e–35 | |
| VPS37 | --- | ||
| ESCRT-II | VPS22/SNF8 | dot2+/SPBC651.05c | 2.3e–36 |
| VPS25 | vps25+/SPBC4B4.06 | 6.3e–16 | |
| VPS36 | vps36+/SPBC3B9.09 | 2.5e–27 | |
| ESCRT-III | VPS2/DID4 | vps2+/SPAC4F8.01 | 2.2e–49 |
| VPS20 | vps20+/SPBC215.14c | 1.3e–19 | |
| VPS24 | vps24+/SPAC9E9.14 | 1.1e–27 | |
| VPS32/SNF7 | vps32+/SPBC215.14 | 2.3e–38 | |
| Vps4 | VPS4 | vps4+/SPAC2G11.06 | 2.1e–145 |
| Deubiquitinating enzyme | hAMSH | sst2+/SPAC19B12.10 | 2.7e–56 |
| DOA4 | ubp1+/SPCC16A11.12c | 3.9e–50 | |
| ubp4+/SPBC18H10.08c | 2.6e–49 | ||
| ubp12+/SPCC1494.05 | 2.7e–56 |
*Sac. cerevisiae homologues are indicated with the exception of human AMSH (hAMSH).
†The fission yeast proteins were identified by screening the Sch. pombe genome database for new homologues of the known Sac. cerevisiae proteins using the blast program for sequence alignments (http://www.genedb.org/genedb/pombe/blast.jsp). Probability scores are shown as E-values. For Sst2p, the human AMSH protein sequence was used as a query.