Fig. 8.
Survival of DU145 cells in clonogenic experiments after pretreatment with O6-benzylguanine (O6-BG), followed by treatment with KS119. Cells were pretreated for 4 h with 100 and 20 μM O6-BG, then exposed to 1–10 μM KS119 (oxygenated, panel A and panel C) (oxygen-deficient, panel B and panel D). All points are the result of at least three independent experimental determinations ±SEM.