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. Author manuscript; available in PMC: 2010 Jun 15.
Published in final edited form as: Biochem Pharmacol. 2009 Dec 11;79(11):1553–1561. doi: 10.1016/j.bcp.2009.12.004

Table 1.

LC50 values in μM for cell lines deficient in AGT under oxygen deficiency (OD) or oxygenation (O).

Agent U251
 EMT6
 CHO/AA8
OD O OD O OD O
KS119 0.8a (6.8)b >5.0 (<1.5) 0.5 (28) 3.2 (6.9) 0.6 (11.8) 3.4 (2.8)
Onrigin 5.3 (1.0) 6.9 (1.1) 10 (1.4) 18 (1.2) 15 (0.47) 7.8 (1.2)
90CE 5.4 (1.0) 7.3 (1.0) 14 (1.0) 22 (1.0) 7.1 (1.0) 9.4 (1.0)
a

Values are the result of at least three independent determinations.

b

The fold difference in cytotoxicity between KS119 or onrigin and 90CE was determined by dividing the measured LC50 value of 90CE by that of onrigin or KS119. These values are in agreement with the predicted maximum values expected by calculations using the 90CE flux in cells in model systems.