Table 2.

Effect of systemic pre-treatment with AMPH (2 mg/kg, i.p.) on DAT kinetic parameters measured ex vivo 45 min later in rat dSTR or NAc synaptosomes

Condition	Vmax (pmol/min/mg protein)	Km (nM)
dSTR, Control	46 ± 4.5	57 ± 4.5
dSTR, AMPH	18 ± 1.0*	35 ± 8.2
NAc, Control	18 ± 3.6	81 ± 21
NAc, AMPH	8.7 ± 1.9†	120 ± 30

N = 4-5 per condition and brain region.

^*p < 0.05 versus dSTR control

^†p < 0.05 versus NAc control; paired t-test.