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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Cell Mol Bioeng. 2010 Jun 1;3(2):139–150. doi: 10.1007/s12195-010-0121-3

Figure 5.

Figure 5

Evolutionary conservation of the Adaptive Domain in nesprin-1 and nesprin-2. (A) Amino acid sequence of the AD of nesprin-1 and nesprin-2 from human, mouse, Bos taurus, chicken and Zebrafish (residues 558-786 in human nesprin-1 isoform, AF444779). Overlines indicate left and right halves of the putative ‘divided LEM-like domain’.8 Underlines in human nesprin-1 indicate ‘Hot loops’ (high mobility) predicted by DisEMBL. The V729L mutation (boxed) causes Emery-Dreifuss muscular dystrophy.21 (B) Schematic diagrams to scale, showing the relative positions of the ‘divided LEM-like domain in nesprin-1α8, disordered regions predicted by the ‘loops/coils’ definition (DisEMBL), disordered regions predicted by the ‘hot-loops’ definition (DisEMBL), and secondary possible structure (predicted by PSIPRED). Star highlights residue V729.