Table 4.
Haplotype and genotype patterns association with heroin addiction
| a. Haplotypes | ||||
|---|---|---|---|---|
| SNPs | Gene | Haplotypea | P-value | Effect |
| rs510769-rs3778151 | OPRM1 | CT | 0.0006 | protection |
| rs1534891-rs6001093-rs135757 | CSNK1E | AGT | 0.0007 | protection |
| rs1893679-rs694066 | GAL | GA | 0.0012 | risk |
| rs510769-rs3778151 | OPRM1 | TC | 0.0033 | risk |
| rs3758987-rs11606194 | HTR3B | TT | 0.0064 | protection |
| rs204055-rs2236857-rs2298896 | OPRD1 | TCG | 0.0067 | risk |
| b. Multi locus genotype patterns | ||
|---|---|---|
| SNPs | Gene | P-value |
| rs510769-rs3778151 | OPRM1 | 0.005 |
| rs2236857-rs3766951 | OPRD1 | 0.013 |
| rs2236861-rs510769 | OPRD1/OPRM1 | 0.0005 |
a
Alleles are in the sense orientation of the relevant gene.
SNPs that gave significant P-values on single SNP analysis (Table 3) are in bold.