Oligodendroglial pathology as a result of 3NP treatment. In order to examine the effects of 3NP treatment on oligodendrocytes, levels of APC, an oligodendrocytic marker, were examined in the corpus callosum of vehicle- and 3NP-treated NTg and vehicle- and 3NP-treated MBP-hasyn mice (A–D, respectively, and analyzed in E). APC levels were also examined in the cerebellar white matter of vehicle- and 3NP-treated NTg and vehicle- and 3NP-treated MBP-hasyn mice (F–I, respectively, and analyzed in J). Scale bar = 200 μM. *Significant difference (P < 0.05, one-way ANOVA and post hoc Fisher). [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]