Figure 2.

Mean basal ganglia responses to gains, penalties, and no change feedback. For the three SNPs depicted (rs10494996, rs2841608, rs2841616), gains elicited robust activation in individuals possessing two copies of an allele previously associated with antidepressant response (“protective variant”). Note that for rs10494996, individuals homozygous for this allele were grouped with heterozygotes to increase sample size in the protected group (AA homozygotes: n = 2; AG heterozygotes: n = 8; GG homozygotes: n = 21).