Table I.

SNPs with a priori hypotheses

SNP	Position	Region	Polymorphism groups	HWE P‐value
rs2841616	chr1:213240461	Promoter	GG (n = 9), AA/AG (n = 22)	0.85
rs2841608	chr1:213257870	Intron	CC (n = 10), AA/AC (n = 21)	1.00
rs12136349	chr1:213317850	Intron/promoter	GG (n = 21), AG/AA (n = 10)	0.58
rs10494996	chr1:213486294	Downstream	AA/AG (n = 10), GG (n = 21)	0.58

Note. HWE: Hardy–Weinberg Equilibrium. For each polymorphism group, the protective allele group is listed first. Position: the chromosomal and base pair location. Region: the region on the gene in which the SNP is located. Of note, rs2841608 and rs12136349 were imputed based upon rs2802643 and rs7528988, which have r ² of 1 with the imputed SNPs; accordingly, the listed HWE statistics are for the typed SNPs rs2802643 and rs7528988.