Fig. 5.
Effect of cocaine on mitochondrial membrane potential. The glial cells (2 × 104 per well) were seeded in 96 well plates with complete RPMI 1640 media containing 10% FBS and were treated with various concentrations of cocaine (2–6 mM) for 24 h. Membrane potential was evaluated fluorometrically as a measure of rhodamine- 123 uptake. Data were represented as mean ± SEM (n = 12, *P < 0.01, highly significant in comparison to control, One-way ANOVA, Dunnett’s multiple comparison test)