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. Author manuscript; available in PMC: 2011 Jun 16.
Published in final edited form as: J Am Chem Soc. 2010 Jun 16;132(23):8087–8097. doi: 10.1021/ja101524z

Figure 10.

Figure 10

Plausible models of dendrimer-lipid interaction at low and high concentrations. (A) Model ofdendrimer-lipid interactions at low dendrimer concentrations.. The dendrimer can traeverse the bilayer by first binding to the surface of the outer leaflet, inserting into the membrane making contacts at both leaflets, and finally dissociating from the membrane on the opposite side. (B) At higher dendrimer concentrations the structural integrity of the membrane is weakened and dendrimer-lipid micelles are formed.