Table 2.
Immunoreactivity scores for claudin-1, -3, -4, -5 and-7 in different types of pulmonary cells in developing human lung during various gestational periods.
| Claudin type | Pseudo-glandular period day 52-week 16 13 cases (scores/number of cases) |
Canalicular period weeks 16-28 17 cases (scores/number of cases) |
Saccular period weeks 28-36 9 cases (scores/number of cases) |
Alveolar period weeks 36-40 8 cases (scores/number of cases) |
|---|---|---|---|---|
| Claudin-1 | ||||
| bronchus | +/10, ++/3 | +++/17 | ++/8, +++/1 | ++/1, +++/7 |
| bronchioles | +/5, ++/12 | +/8, ++/1 | ++/5, +++/3 | |
| - large | +/13 | |||
| - small | negative/13 | |||
| alveolus | # negative/13 | negative/17 | negative/9 | negative/8 |
| endothelial cell | negative/13 | negative/17 | negative/9 | negative/8 |
| Claudin-3 | ||||
| bronchus | +++/13 | +++/17 | +++/9 | +++/8 |
| bronchiolus | ++/6, +++/7 | +++/17 | +++/9 | +++/8 |
| alveolus | # +/4, ++/9 | * +/8, ++/9 | & +/7, ++/2 | & +/7,++/1 |
| endothelial cell | negative/13 | negative/17 | negative/9 | negative/8 |
| Claudin-4 | ||||
| bronchus | +++/13 | +++/17 | +++/9 | +++/8 |
| bronchiolus | +++/13 | +++/17 | +++/9 | +++/8 |
| alveolus | # +/3, ++/10 | * +/4, ++/13 | & +/5 ++/4 | & +/2 ++/6 |
| endothelial cell | negative/13 | negative/17 | negative/9 | negative/8 |
| Claudin-5 | ||||
| bronchus | +/13 | +/17 | +/9 | +/8 |
| bronchiolus | +/13 | +/17 | +/9 | +/8 |
| alveolus | # +/13 | * +/17 | negative/9 | negative/8 |
| endothelial cell | +++/13 | +++/17 | +++/9 | +++/8 |
| Claudin-7 | ||||
| bronchus | +++/13 | +++/17 | +++/9 | +++/8 |
| bronchiolus | ++/3, +++/10 | +++/17 | +++/9 | +++/8 |
| alveolus | # +/13 | * +/7,++/9, +++/1 | & +/8, ++/1 | & +/8 |
| endothelial cell | negative/13 | negative/17 | negative/9 | negative/8 |
# = small developing airways, not alveoli
* = pretype II cells
& = type II pneumocytes