Table 3.
Correlation between the IL-6, VEGF, CRP, and clinicopathological parameters
| VEGF pg/ml | IL-6 pg/ml | CRP mg/dL | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | Median (range) | p | Mean | Median (range) | p | Mean | Median (range) | p | |
| Sex | |||||||||
| Male | 656 | 567 (131-3242) | 0048 | 13.12 | 5.03 (1.02-139.17) | 0.019 | 1.24 | 0.25 (0.01-18.40) | 0.827 |
| Female | 567 | 469 (123-2001) | 16.14 | 7.71 (1.25-90.06) | 0.83 | 0.16 (0.00-8.41) | |||
| Age | |||||||||
| < 60 | 634 | 569 (123-1620) | 0.363 | 15.31 | 5.61 (1.02-90.06) | 0.854 | 1.15 | 0.17 (0.02-8.41) | 0.610 |
| ≥ 60 | 593 | 494 (131-3242) | 13.70 | 6.63 (1.58-139.17) | 0.98 | 0.24 (0.00-18.40) | |||
| CEA | |||||||||
| ≤ 5 | 583 | 493 (123-32.42) | 0.038 | 12.98 | 5.70 (1.02-94.11) | 0.255 | 1.14 | 0.20 (0.01-18.40) | 0.824 |
| > 5 | 680 | 635 (131-1619) | 18.91 | 8.0 (1.58-139.17) | 0.80 | 0.25 (0.02-6.97) | |||
| Primary tumor | |||||||||
| pT1 | 452 | 422 (123-892) | 0.540 | 18.60 | 3.93 (2.18-94.11) | 0.549 | 1.02 | 0.16 (0.01-6.22) | 0.905 |
| pT2 | 565 | 471 (139-1585) | 14.78 | 7.74 (1.02-70.96) | 0.67 | 0.33 (0.02-3.43) | |||
| pT3 | 639 | 546 (126-3242) | 13.35 | 6.02 (1.25-139.17) | 1.17 | 0.24 (0.00-18.40) | |||
| pT4 | 606 | 567 (174-1216) | 17.00 | 6.05 (3.44-88.96) | 0.77 | 0.53 (0.03-2.29) | |||
| Regional Lymph nodes | |||||||||
| N0 | 652 | 539 (123-3242) | 0.557 | 13.32 | 6.49 (1.02-94.11) | 0.533 | 1.04 | 0.26 (0.01-10.09) | 0.432 |
| N1 | 579 | 562 (139-1098) | 8.53 | 5.66 (1.49-30.02) | 1.23 | 0.13 (0.00-18.40 | |||
| N2 | 560 | 432 (156-1620) | 27.92 | 6.31 (1.25-139.17) | 0.79 | 0.20 (0.02-7.83) | |||
| Lymph node ratio | |||||||||
| pNr1 0.01-0.11 | 634 | 558 (123-3242) | 0.215 | 11.89 | 5.58 (1.02-94.11) | 0.242 | 1.16 | 0.25 (0.0-18.40) | 0.352 |
| pNr2 0.12-0.24 | 495 | 495 (145-1619) | 20.86 | 6.31 (1.91-90.06) | 0.76 | 0.11 (0.00-6.97) | |||
| pNr3 0.25-0.92 | 446 | 430 (156-1068) | 26.10 | 10.15 (1.25-139.17) | 0.54 | 0.17 (0.04-2.18) | |||
| Size | |||||||||
| < 5 cm | 550 | 463 (123-3242) | 0.012 | 10.58 | 5.15 (1.02-76.79) | 0.129 | 1.32 | 1.15 (0.00-18.40) | 0.739 |
| ≥ 5 cm | 655 | 577 (126-2001) | 12.28 | 7.15 (1.25-139.17) | 0.84 | 0.25 (0.01-8.41) | |||
| Stage | |||||||||
| Stage I | 547 | 471 (123-1586) | 0.320 | 17.60 | 5.52 (1.02-94.11) | 0.907 | 0.88 | 0.16 (0.01-6.22) | 0.681 |
| Stage II | 711 | 573 (126-3242) | 10.94 | 10.94 (1.58-93.08) | 1.13 | 0.28 (0.01-10.09) | |||
| Stage III | 553 | 495 (139-1620) | 15.67 | 5.97 (1.25-139.47) | 1.07 | 0.13 (0.00-18.40) | |||
| Differentiation | |||||||||
| Well | 644 | 495 (123-3242) | 0.234 | 12.07 | 5.49 (1.02-94.11) | 0.275 | 0.75 | 0.25 (0.01-6.97) | 0.957 |
| Moderate | 541 | 511 (133-1620) | 18.07 | 7.45 (1.49-139.17) | 1.60 | 0.15 (0.00-18.40) | |||
| Poor | 531 | 520 (174-1083) | 7.45 | 8.42 (2.65-11.88) | 0.28 | 0.20 (0.00-0.54) | |||
| Mucinous | 805 | 663 (448-1258) | 13.35 | 8.30 (1.25-39.03) | 0.52 | 0.18 (0.02-1.60) | |||