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. 2010 Jun 15;5(6):e11112. doi: 10.1371/journal.pone.0011112

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Henkel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Current fluctuates between a closed (c) and two (o₁, o₂) conductance levels (A). Channel fluctuations recorded in symmetric 500 mM KCl in trans and cis chamber. (B) Example of channel opening in one step between closed (c) and maximal conductance (o₂) and closing with an intermediate rest at low conductance level (*). (C) Example of intermediate closures from maximal conductance (o₂) to sub-conductance levels, which are indicated by symbols (•,). (D) I/V relation of the small (o₁) and large current fluctuation (o₂). Experiments performed in symmetrical 500 mM KCl. The I/V relations in D were obtained from measurements of channel conductance evoked by peptide from sPB1-F2_pr8, sPB1-F2_sf and sPB1-F2_bf. (E) examples of channel type current fluctuations between the closed (c) and two conductance levels (o₁, o₂) evoked by sPB1-F2 peptide from influenza Puerto Rico strain (sPB1-F2_pr8), Spanish flu strain (sPB1-F2_sf) and bird flu strain (sPB1-F2_bf). Measurements in A-C were done in symmetric 500 mM KCl in trans and cis chamber at a voltage of +80 mV; all peptides were added to the buffer at final concentration of 1 µM.

Inline graphic — Current fluctuates between a closed (c) and two (o₁, o₂) conductance levels (A). Channel fluctuations recorded in symmetric 500 mM KCl in trans and cis chamber. (B) Example of channel opening in one step between closed (c) and maximal conductance (o₂) and closing with an intermediate rest at low conductance level (*). (C) Example of intermediate closures from maximal conductance (o₂) to sub-conductance levels, which are indicated by symbols (•,). (D) I/V relation of the small (o₁) and large current fluctuation (o₂). Experiments performed in symmetrical 500 mM KCl. The I/V relations in D were obtained from measurements of channel conductance evoked by peptide from sPB1-F2_pr8, sPB1-F2_sf and sPB1-F2_bf. (E) examples of channel type current fluctuations between the closed (c) and two conductance levels (o₁, o₂) evoked by sPB1-F2 peptide from influenza Puerto Rico strain (sPB1-F2_pr8), Spanish flu strain (sPB1-F2_sf) and bird flu strain (sPB1-F2_bf). Measurements in A-C were done in symmetric 500 mM KCl in trans and cis chamber at a voltage of +80 mV; all peptides were added to the buffer at final concentration of 1 µM.