. 2010 Jun 16;102(12):846–858. doi: 10.1093/jnci/djq173

Table 2.

Distribution of risk in simulated populations based on the combined multiplicative effect of all variants discovered in genome-wide association studies

Cancer type	Variants considered	Risk in percentile of simulated risk^*					RR in upper vs lower decile (95% CI)	RR in upper vs lower quartile (95% CI)
Cancer type	Variants considered	10th	25th	50th	75th	90th	RR in upper vs lower decile (95% CI)	RR in upper vs lower quartile (95% CI)
Colorectal	10	66.4	78.3	95.6	113.3	139.6	2.75 (2.41 to 3.14)	2.10 (1.91 to 2.31)
Prostate	26	43.2	58.7	84.8	123.1	174.4	6.85 (6.02 to 7.79)	4.08 (3.67 to 4.53)
Testicular	3	39.8	54.5	101.4	138.9	152	7.99 (7.06 to 9.03)	4.19 (3.89 to 4.52)
Thyroid	2	58.9	58.9	80.8	131.8	141.4	4.45 (3.96 to 5.01)	4.09 (3.75 to 4.46)

Risks are shown standardized against the mean simulated risk in the population (mean = 100). CI = confidence interval; RR = relative risk.