Table 1. List of SNP associated with positive ELISA test to MAP infection indentified by Genome Wide Association study in Holstein cattle.
SNP name | BTA | Position (bp) | N | effB Q.2 | P1df | Pc1df | Call Rate | Q.2 | P.11 | P.12 | P.22 | Pexact H-W test | Coding Minor/major allele |
ARS-BFGL-NGS-57278 | 12 | 69663832 | 903 | 0.157 | 2.29e-06 | 1.04e-06 | 0.97 | 0.11 | 722 | 167 | 14 | 0.22 | G/A |
BTA-95991-no-rs | 12 | 69599639 | 925 | 0.154 | 3.14e-06 | 1.44e-06 | 1 | 0.11 | 743 | 167 | 15 | 0.12 | G/A |
BTB-01626215 | 0 | 0 | 909 | 0.168 | 7.28e-06 | 3.55e-06 | 0.98 | 0.10 | 732 | 177 | 0 | 0.0001 | G/A |
ARS-BFGL-NGS-101584 | 12 | 68553182 | 925 | 0.134 | 1.50e-05 | 7.70e-06 | 1 | 0.12 | 709 | 198 | 18 | 0.37 | G/A |
ARS-BFGL-NGS-8531 | 9 | 46362363 | 925 | 0.097 | 3.59e-05 | 1.94e-05 | 1 | 0.27 | 496 | 362 | 67 | 0.93 | A/G |
ARS-BFGL-NGS-17731 | 11 | 89695127 | 923 | −0.082 | 6.95e-05 | 3.93e-05 | 0.99 | 0.42 | 310 | 445 | 168 | 0.73 | A/G |
ARS-BFGL-NGS-105846 | 12 | 67342543 | 925 | 0.113 | 1.17e-04 | 6.83e-05 | 1 | 0.15 | 659 | 247 | 19 | 0.53 | A/G |
BTB-02056135 | 8 | 37257076 | 925 | −0.084 | 1.19e-04 | 7.02e-05 | 1 | 0.37 | 356 | 446 | 123 | 0.40 | A/C |
ARS-BFGL-NGS-37647 | 27 | 45253563 | 925 | −0.086 | 1.19e-04 | 7.55e-05 | 1 | 0.11 | 321 | 484 | 120 | 0.003 | A/G |
BTB-01470661 | 12 | 69808111 | 900 | 0.135 | 1.32e-04 | 7.80e-05 | 0.97 | 0.11 | 696 | 203 | 1 | 4.75e-05 | C/A |
SNP name: snp name as in the bovine 50K SNP Chip data.
BTA: Bos Taurus Chromosome.
effB Q.2.: effect of the minor allele (B allele).
P1df: raw p-values before adjustment for Genomic Control.
Pc1df: p-values adjusted for Genomic Control.
Q.2.: frequency of the minor allele allele (B allele).
Pexact H-W test = exact p-value for the test of Hardy-Weinberg estimated in cases and controls together.