Figure 1.

Historical. Figure 1 depicts copies of illustrations of mammary “Spindelzollensarkom” from Apolant 1907 (a) “carcinosarcoma” from Dunn 1945 (b), mouse mammary “EMT-type” tumor with immunohistochemical stains for cytokeratin 8/18 (c) and smooth muscle actin (d) from White et al. [47] 2001 and a “triple negative” human breast cancer with undifferentiated cells that stain for vimentin (e) and cytokeratin 8/18 (f). Apolant associated his spindle cell and mixed tumors with transplantation [1]. Dunn associated her mixed tumor with tissue culture and explantation [23]. White found spontaneous EMT-type tumors with loss of the ILK1 transgene and up regulation of Snail [47]. The dual staining, triple negative phenotype in human breast cancer is not recognized as a specific subset or with a specific diagnostic term.