Table 2.
VH gene usaCDR13 |
CDR2 |
CDR3 |
||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mice | mAb1 | GL | Jh | 31 | 32 | 33 | 34 | 35 | 50 | 51 | 52 | a | 53 | 54 | 55 | 56 | 57 | 58 | 59 | 60 | 61 | 62 | 63 | 64 | 65 | 95 | 96 | 97 | 98 | 99 | 100 | a | b | c | d | e | f | i | j | k | 101 | 102 |
B6.Sle1 z-#1 | 1A1G12a | J558.75.177 | 4 | R | Y | W | L | H | R | I | D | P | N | S | G | A | A | K | Y | N | E | K | F | K | I | P | Y | S | N | Y | G | G | A | M | D | Y | ||||||
B6.Sle1 z -#2 | 1BD2b | J558.53.146 | 2 | T | Y | W | I | H | N | I | K | P | S | N | G | N | T | N | Y | N | E | N | F | N | K | R | R | Y | N | Y | Y | D | L | D | Y | |||||||
B6.Sle1 z -#3 | 1CA4c | J558.75.177 | 2 | N | Y | W | I | H | R | I | D | L | N | S | G | G | I | K | Y | N | E | N | F | K | N | E | G | F | D | G | V | D | Y | |||||||||
1CB3 | J558.55.149 | 2 | S | Y | W | I | T | D | I | Y | P | G | S | R | S | T | N | Y | N | E | K | F | K | N | S | K | R | I | W | R | N | S | F | D | Y | |||||||
1CD3 | 7183.19.36 | 4 | D | F | Y | M | A | H | I | N | Y | D | G | S | N | T | Y | Y | L | D | S | L | K | S | A | Q | L | R | N | Y | A | M | D | Y | ||||||||
1CE6 | J558.72.173 | 2 | S | Y | W | M | H | E | I | Y | P | S | D | S | Y | T | N | Y | N | Q | K | F | K | G | R | G | N | L | G | K | V | F | D | Y | ||||||||
1CE7 | 36–60.6.70 | 4 | S | Y | Y | W | N | Y | I | S | Y | D | G | S | N | N | Y | N | P | S | L | K | N | D | D | Y | D | Y | D | G | D | G | Y | Y | Y | A | M | D | Y | |||
B6.Sle1 z -#4 | 1DB2 | J558.26.116 | 2 | D | Y | Y | M | H | D | F | N | P | N | N | D | V | T | S | Y | N | Q | K | F | K | G | R | G | L | W | L | R | R | F | Y | F | L | D | Y | ||||
1DC1e | J558.26.116 | 3 | D | N | Y | I | N | D | I | N | A | K | N | G | G | S | R | Y | S | Q | K | F | K | G | E | D | R | D | Y | D | G | G | F | A | Y | |||||||
1DC3 | J558.84.190 | 3 | S | Y | G | I | S | E | I | Y | P | R | S | G | N | T | Y | Y | N | E | K | F | K | G | R | A | W | F | A | Y | ||||||||||||
1DC5 | J558.83.189 | 4 | N | Y | W | M | N | Q | I | Y | P | G | D | G | D | T | N | Y | N | G | K | F | K | G | H | D | Y | D | G | A | W | F | A | Y | ||||||||
1DC7f | J558.26.116 | 3 | D | Y | Y | M | N | D | I | N | P | N | N | G | G | T | S | Y | N | Q | K | F | K | G | S | R | G | N | A | W | F | A | Y | |||||||||
1DC9 | J558.42.132 | 1 | G | Y | Y | M | N | E | I | N | P | T | N | G | I | T | T | Y | N | Q | K | F | K | A | K | T | D | V | ||||||||||||||
1DE1 | J606.1.79 | 3 | N | Y | W | M | N | Q | I | R | S | D | N | Y | A | T | H | Y | A | E | S | V | K | G | L | I | Q | G | F | A | Y | |||||||||||
1DE4 | 7183.19.36 | 4 | D | Y | Y | M | T | N | I | N | Y | D | G | S | I | T | Y | Y | L | D | S | L | K | S | A | Q | L | R | N | Y | A | M | D | Y | ||||||||
1DG5d | J558.55.149 | 2 | S | Y | W | I | T | D | I | Y | P | G | S | R | S | T | N | Y | N | E | K | F | K | N | S | K | R | I | W | R | N | S | F | D | Y | |||||||
B6.Sle1 z -#5 | 1EA9 | J558.72.173 | 2 | S | Y | W | T | H | E | I | D | P | S | D | S | Y | T | N | Y | N | Q | K | F | K | D | R | G | S | S | F | D | Y | ||||||||||
1EA10 | J558.53.146 | 2 | S | Y | W | M | H | D | I | N | P | S | N | G | G | T | N | Y | N | E | K | F | K | T | S | S | A | F | I | N | S | F | D | Y | ||||||||
1EB2 | J558.67.166 | 4 | T | Y | W | M | H | V | T | H | P | N | S | G | F | T | N | Y | S | G | K | F | K | R | T | N | W | E | R | N | Y | A | M | D | Y | |||||||
1EB5 | 7183.20.37 | 4 | D | Y | G | M | H | Y | I | S | S | G | S | S | T | I | Y | Y | A | D | T | V | K | G | R | G | Y | G | Y | A | M | D | Y | |||||||||
1EC1 | J558.84.190 | 1 | S | Y | G | I | S | E | I | Y | P | R | S | G | N | T | Y | Y | N | E | K | F | K | G | E | R | G | L | R | R | Y | F | D | V | ||||||||
1ED6 | J558.22.112 | 4 | D | Y | N | M | H | Y | I | N | P | N | N | G | G | T | N | Y | N | Q | K | F | K | G | V | N | W | D | A | A | M | D | Y | |||||||||
1ED7 | 7183.14.25 | 2 | N | Y | A | M | S | Y | I | S | S | G | G | D | Y | I | Y | Y | G | D | T | V | Q | G | E | G | E | I | E | I | Y | D | Y | |||||||||
1ED9 | J558.72.173 | 2 | S | Y | W | M | H | K | I | D | P | S | D | S | Y | T | N | Y | N | Q | K | F | K | G | G | S | S | R | Y | F | D | Y | ||||||||||
1EE5g | J558.26.116 | 4 | D | H | Y | V | N | D | I | N | P | N | N | G | G | T | S | Y | N | Q | K | F | K | D | T | W | G | G | T | N | G | M | D | Y | ||||||||
1EG4 | SM7.2.49 | 1 | D | Y | Y | M | H | R | I | D | P | E | D | G | E | T | K | Y | A | P | K | F | Q | G | E | P | I | Y | Y | G | Y | H | V | G | Y | F | D | V | ||||
1EG8 | Q52.9.29 | 4 | S | Y | G | I | S | V | I | W | T | G | E | G | T | Y | Y | N | S | A | L | K | S | T | Y | S | N | Y | R | T | M | D | Y | |||||||||
1EH1 | J558.4.93 | 2 | S | Y | W | M | H | Y | I | N | P | S | S | G | Y | T | K | Y | N | Q | K | F | K | G | T | Y | Y | S | N | Y | F | V | D | Y | ||||||||
1EH2 | J558.4.93 | 4 | G | Y | W | M | H | Y | I | N | P | S | T | N | Y | P | N | Y | N | Q | K | F | K | D | S | T | G | A | M | D | Y | |||||||||||
1EH4 | J558.85.191 | 3 | S | S | W | M | N | R | I | Y | P | G | D | G | D | T | N | Y | N | G | K | F | K | G | S | E | G | G | Y | R | F | A | Y | |||||||||
1EH5 | 7183.19.36 | 2 | D | Y | Y | M | A | N | I | N | Y | D | G | S | S | T | Y | Y | L | D | S | L | K | S | V | K | Y | S | N | Y | D | Y | ||||||||||
1EJ5 | J558.67.166 | 2 | S | Y | W | M | F | M | I | P | P | N | S | G | N | T | N | Y | N | E | K | F | K | R | R | N | L | Y | G | T | L | D | Y |
1 Footnotes are as listed in Table 1.
Displayed are the HC CDR residues, with mutated residues in bold. H52b and H52c have been omitted as only two Abs had residues at these positions.