Table 3.
V-kappa usage2 |
CDR13 |
CDR2 |
CDR3 |
|||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Mice | mAb1 | Jk | 24 | 25 | 26 | 27 | a | b | c | d | e | f | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 50 | 51 | 52 | 53 | 54 | 55 | 56 | 89 | 90 | 91 | 92 | 93 | 94 | 95 | 96 | 97 | |
B6.Sle1 z -#1 | 1A3F1a | 23–48 | 5 | R | A | S | Q | N | V | G | T | N | V | H | S | A | S | K | S | F | S | Q | Q | S | K | T | W | P | M | L | ||||||
B6.Sle1 z -#2 | 1BD2 b | 12–44 | 5 | Q | A | S | E | N | I | A | S | D | L | P | D | A | K | T | L | A | D | Q | H | Y | Y | G | T | P | L | T | ||||||
B6.Sle1 z -#3 | 1CA4 c | ai4 | 5 | T | A | R | S | S | V | S | S | S | Y | L | H | R | T | S | N | L | A | S | H | Q | Y | H | R | S | P | L | T | |||||
1CB3 | 21–10 | 5 | R | A | S | E | S | V | D | S | Y | G | N | S | F | M | H | L | A | S | N | L | E | S | Q | Q | N | N | E | D | P | L | T | |||
1CD3 | ai4 | 2 | T | A | S | S | S | V | S | S | S | S | L | H | S | T | S | I | L | A | S | H | Q | Y | R | R | S | P | P | I | ||||||
1CE6 | ||||||||||||||||||||||||||||||||||||
1CE7 | ai4 | 2 | T | A | S | S | S | V | T | S | S | R | L | H | A | T | S | N | L | A | S | H | Q | Y | H | R | S | P | P | I | ||||||
B6.Sle1 z -#4 | 1DA2 e | 19–23 | 1 | K | A | S | Q | D | V | G | T | A | V | A | W | A | T | T | R | H | T | Q | Q | Y | S | S | Y | P | - | T | ||||||
1DB2 | ce9 | 2 | R | A | G | Q | D | I | S | N | Y | L | N | F | T | S | K | L | H | S | Q | Q | G | N | S | L | P | Y | T | |||||||
1DC1 e | 23–39 | 5 | R | A | S | Q | S | I | S | D | Y | L | H | Y | A | S | Q | S | I | S | Q | N | G | H | S | F | P | L | T | |||||||
1DC5 | ai4 | 5 | T | A | R | S | S | V | S | S | S | Y | L | H | S | T | S | N | L | A | S | H | Q | Y | H | R | S | P | L | T | ||||||
1DC7 f | ai4 | 2 | T | A | R | S | S | V | S | S | R | Y | L | H | S | T | S | S | L | A | S | H | Q | Y | H | R | S | P | Y | T | ||||||
1DC9 | 21-2 | 4 | R | A | S | E | S | V | D | N | Y | G | I | S | F | M | D | A | A | S | N | Q | R | S | Q | Q | T | K | E | I | P | F | T | |||
1DD10f | 19-15 | 2 | K | A | S | Q | N | V | G | T | N | V | A | S | A | S | Y | R | Y | S | Q | Q | Y | N | S | Y | P | Y | T | |||||||
1DE1 | cr1 | 1 | R | S | S | Q | S | I | V | H | S | N | G | N | T | Y | L | E | K | V | S | N | R | F | S | F | Q | G | S | H | V | P | W | T | ||
1DE4 | ai4 | 2 | T | A | S | S | S | V | T | S | S | R | L | H | A | T | S | N | L | A | S | H | Q | Y | H | R | S | P | P | I | ||||||
B6.Sle1 z -#5 | 1EA9 | ai4 | 2 | R | A | S | E | N | I | Y | S | Y | L | T | S | T | S | N | L | A | S | L | Q | Y | H | R | S | P | Y | T | ||||||
1EA10 | 12–44 | 5 | T | A | S | S | S | V | R | S | S | Y | L | H | N | A | K | T | L | A | D | Q | H | H | F | G | T | P | L | T | ||||||
1EB2 | 23–39 | 5 | R | A | S | Q | S | I | S | D | Y | L | H | Y | A | S | Q | S | I | S | Q | N | G | H | S | F | P | L | T | |||||||
1EB5 | ai4 | 2 | T | A | S | S | S | V | R | S | I | Y | L | Y | N | T | S | N | L | T | S | H | Q | H | H | R | S | P | Y | T | ||||||
1EC1 | bb1 | 5 | R | S | S | Q | S | L | V | H | S | N | G | N | T | Y | L | H | K | V | S | N | R | F | S | S | Q | S | T | H | V | P | L | T | ||
1ED6 | 23–39 | 1 | R | A | S | Q | S | I | S | D | Y | L | H | Y | A | S | Q | S | I | S | Q | N | G | H | S | F | P | P | T | |||||||
1ED7 | at4 | 1 | S | A | S | S | S | V | S | Y | M | Y | D | T | S | N | L | A | S | Q | Q | W | S | S | Y | P | W | T | ||||||||
1ED9 | 23–43 | 2 | R | A | S | Q | S | I | S | N | N | L | H | Y | A | S | Q | S | I | S | Q | Q | S | N | S | W | Y | - | T | |||||||
1EE5g | ai4 | 2 | T | A | R | L | S | V | R | S | S | Y | L | H | S | T | S | S | L | A | S | H | Q | C | H | R | S | P | Y | T | ||||||
1EG4 | 12–44 | 4 | R | A | S | E | N | I | Y | S | F | L | A | N | A | K | T | L | A | E | H | H | H | Y | G | T | P | F | T | |||||||
1EG8 | kn4 | 1 | S | A | S | S | S | I | S | Y | M | H | D | T | S | K | L | A | S | H | Q | R | S | S | C | P | W | T | ||||||||
1EH1 | bb1 | 4 | R | S | S | Q | S | L | V | H | S | N | G | N | T | Y | L | H | K | V | S | N | R | F | S | S | Q | S | T | H | V | T | W | T | ||
1EH2 | bb1 | 2 | R | S | S | Q | S | L | L | H | S | N | G | N | T | Y | L | H | K | V | S | N | R | F | S | S | Q | S | T | H | V | P | Y | T | ||
1EH4 | ||||||||||||||||||||||||||||||||||||
1EH5 | 8–21 | 4 | K | S | S | Q | S | L | L | N | S | R | T | R | K | N | Y | L | A | W | A | S | T | R | E | S | K | Q | S | Y | N | L | F | - | T | |
1EJ5 | bv9 | 1 | R | A | S | Q | D | I | G | S | S | L | N | A | T | S | S | L | D | S | L | Q | Y | A | T | A | W | - | T |
1 The entries for 1EH4, 1CE6, and clone (d) have been omitted as these mAbs used λ LCs. All other details are as listed in Table 1.