Table 2.
Biodistribution data of all five radiolabelled analogues at time points A, B and C in PC-3 tumour-bearing athymic nude mice injected with 10 pmol peptide, labelled with an activity of 0.5 MBq 111In or 2.5 MBq 99mTc, in a volume of 0.1 ml into a lateral tail vein. Results are the mean and standard deviation of four mice per analogue per time point
| Organ | [111In]MP2653 | [111In]MP2346 | [111In]PESIN | [111In]AMBA | [99mTc]Demobesin-1 |
|---|---|---|---|---|---|
| A. 1 h p.i. (%ID/g ± SD) | |||||
| Blood | 0.2 ± 0.1 | 0.4 ± 0.5 | 0.3 ± 0.1 | 0.2 ± 0.0 | 0.6 ± 0.1 |
| Pancreas | 14.7 ± 3.8 | 9.0 ± 2.5 | 20.8 ± 3.9 | 40.9 ± 3.3 | 23.8 ± 3.2 |
| Kidneys | 2.0 ± 0.3 | 7.9 ± 1.9 | 2.7 ± 1.0 | 3.6 ± 0.7 | 3.2 ± 1.2 |
| Colon | 2.5 ± 0.4 | 2.1 ± 0.4 | 2.9 ± 1.5 | 6.8 ± 0.9 | 2.5 ± 1.2 |
| Tumour | 0.9 ± 0.2 | 2.1 ± 0.9 | 2.3 ± 0.5 | 2.7 ± 0.5 | 3.0 ± 0.4 |
| B. 4 h p.i. (%ID/g ± SD) | |||||
| Blood | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.2 ± 0.0 |
| Pancreas | 11.4 ± 2.5 | 8.9 ± 2.1 | 17.5 ± 2.8 | 40.5 ± 7.6 | 4.1 ± 1.6 |
| Kidneys | 1.2 ± 0.4 | 10.6 ± 1.6 | 1.5 ± 0.4 | 3.4 ± 1.4 | 1.1 ± 0.2 |
| Colon | 1.6 ± 0.6 | 1.8 ± 0.7 | 3.6 ± 0.4 | 5.6 ± 1.2 | 1.2 ± 0.3 |
| Tumour | 0.7 ± 0.2 | 1.4 ± 0.4 | 1.6 ± 0.2 | 1.9 ± 0.3 | 2.2 ± 0.4 |
| C. 24 h p.i. (%ID/g ± SD) | |||||
| Blood | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| Pancreas | 2.4 ± 0.7 | 5.8 ± 1.4 | 14.5 ± 2.8 | 32.9 ± 5.2 | 0.1 ± 0.0 |
| Kidneys | 0.6 ± 0.3 | 2.8 ± 0.9 | 0.7 ± 0.4 | 1.3 ± 0.5 | 0.1 ± 0.0 |
| Colon | 0.8 ± 0.2 | 0.6 ± 0.3 | 1.0 ± 0.4 | 3.2 ± 0.8 | 0.1 ± 0.1 |
| Tumour | 0.4 ± 0.1 | 0.7 ± 0.4 | 1.2 ± 0.2 | 1.6 ± 0.4 | 0.4 ± 0.1 |