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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2009 Oct 30;1804(8):1666–1675. doi: 10.1016/j.bbapap.2009.10.022

Fig. 1. The SIRT1-catalyzed protein deacetylation reaction.

Fig. 1

NAD+ is consumed as a substrate for the deacetylation of target proteins, which are acetylated on specific lysine (Lys) residues. The products in the reaction are deacetylated protein, nicotinamide (NAM), and O-acetyl-ADP-ribose (OAADPR).