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A schematic diagram of the SIRT1-mediated regulation of the CLOCK:BMAL1-dependent circadian transcription. SIRT1 physically interacts with CLOCK, a key clock regulator that heterodimerizes with BMAL1, and deacetylates BMAL1 and histone H3 in a circadian manner at the promoters of circadian clock genes. SIRT1 also interacts with and deacetylates PER2, which heterodimerizes with CRY proteins and inhibits the CLOCK:BMAL1 function, and promotes its degradation. See text for details.
