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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Hepatol Res. 2010 Apr 14;40(5):530–539. doi: 10.1111/j.1872-034X.2010.00635.x

Figure 4.

Figure 4

HIF-dependent regulation of proangiogenic mediators in hypoxic Kupffer cells. Kupffer cells were isolated from HIF-1β-Control and HIF-1β-Deficient mice and exposed to room air or 1% oxygen. Sixteen hours later, VEGF, Ang-1, and Ang-2 mRNA levels were quantified by real-time PCR. aSignificantly different from Kupffer cells exposed to room air (p<0.05). bSignificantly different from Kupffer cells isolated from HIF-1β-Deficient mice and subjected to 1% oxygen (p<0.05). Data are expressed as means ± SEM; n = 3.