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. Author manuscript; available in PMC: 2010 Jun 16.
Published in final edited form as: Synapse. 2005 Nov;58(2):110–121. doi: 10.1002/syn.20185

Fig. 3.

Fig. 3

D1R and D2R antagonists protect against METH-induced DAT depletion. (A) DAT [125I]RTI-121 autoradiographs demonstrate that METH-induced DAT depletion is attenuated by SCH 23390 or raclopride pretreatment (B) in the DM, DL, VM, and VL regions of the striatum, respectively. Antagonists alone had no significant effects on binding sites compared with vehicle + saline. †P < 0.0001 compared with the DM region within each experimental group. !P < 0.0001 compared with the VM region within each experimental group. *P < 0.0001 compared with the corresponding region of vehicle + saline. aP < 0.005 compared with the corresponding region of vehicle + METH (30 mg/kg). n = 6 per group. Cx and CPu refer to the cortex and caudate-putamen (striatum), respectively.