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D1R or D2R antagonists protects from METH-induced terminal toxicity and cell death without preventing hyperthermia. Rectal temperature was recorded every hour starting from 2 h prior to METH treatment. Ambient room temperature was 20–22°C. *P < 0.0001, **P < 0.001, ***P< 0.005, ****P < 0.05 compared with vehicle + saline. Results were from mean ± SEM of 6 animals per experimental group.
