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. Author manuscript; available in PMC: 2010 Jun 16.
Published in final edited form as: Drug Dev Res. 2010 Feb;71(1):44–55. doi: 10.1002/ddr.20347

Fig. 4.

Fig. 4

Type II FAS pathway as found in P. falciparum. MCAT catalyzes the production of malonyl-ACP, which is a substrate for both KASII and KASIII. KASIII catalyzes the condensation of malonyl-ACP with acetyl-CoA, forming acetoacetyl-ACP. This product enters an elongation cycle catalyzed by KAR, HAD, ENR, and KASII. The KASII reaction extends the carbon chain by 2 carbons, noted by increasing the number (n) of CH2 groups in the acyl chain by 2 (n+2). MCAT: malonyl-coenzyme A:ACP transacylase; KAS: β-ketoacyl-ACP synthase; KAR: β-ketoacyl-ACP reductase; HAD: β-hydroxyacyl-ACP dehydratase; ENR: enoyl-ACP reductase.