Table I.
Nuclear receptors and transcription factors reported to localize to mitochondria
Protein | Nuclear Function* |
Proposed Mt Function(s) |
References |
---|---|---|---|
Estrogen receptor alpha | NR | Transcription | [Chen et al., 2004; Demonacos et al., 1996] |
Estrogen receptor beta | NR | Transcription | [Chen et al., 2004] |
Thyroid hormone receptor | NR | Transcription | [Casas et al., 1999; Fernandez-Vizarra et al., 2008; Wrutniak et al., 1995] |
Glucocorticoid receptor | NR | Transcription Apoptosis |
[Demonacos et al., 1993; Psarra and Sekeris 2009] [Adzic et al., 2009; Talaber et al., 2009; Sionov et al., 2006] |
Nur 77 | NR | Apoptosis | [Wang et al., 2009a; Li et al., 2000] |
Retinoid X Receptor | NR | Transcription | [Casas et al., 2003] |
Retinoic Acid Receptor | NR | Unknown | [Berdanier et al., 2001] |
Androgen Receptor | NR | Unknown | [Solakidi et al., 2005] |
PPARγ2 | Coactivator | Interacts with TR |
[Casas et al., 2000] |
SLIRP | NR repressor |
Mitochondrial mRNA stability |
[Baughman et al., 2009] |
CREB | TF | Transcription | [Lee et al., 2005; Ryu et al., 2005; De Rasmo et al., 2009] |
AP-1 | TF | Transcription | [Ogita et al., 2003] |
NF-κB | TF | Transcription Apoptosis |
[Cogswell et al., 2003] [Zamora et al., 2004] |
I-κB | Inhibitor of NF-κB |
Unknown | [Cogswell et al., 2003] |
p53 | TF | Apoptosis mtDNA replication/repair |
[Marchenko et al., 2000] [Yoshida et al., 2003; Bakhanashvili et al., 2009; Bakhanashvili et al., 2008] |
STAT3 | TF | Translation | [Wegrzyn et al., 2009] |
HMGA1 | TF | DNA binding | [Dement et al., 2005] |
Wnt13 | TF | Unknown | [Struewing et al., 2006] |
NR and TF denotes Nuclear Receptor or Transcription Factor, respectively.