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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Environ Mol Mutagen. 2010 Jun;51(5):360–379. doi: 10.1002/em.20571

Table I.

Nuclear receptors and transcription factors reported to localize to mitochondria

Protein Nuclear
Function*
Proposed Mt
Function(s)
References
Estrogen receptor alpha NR Transcription [Chen et al., 2004;
Demonacos et al., 1996]
Estrogen receptor beta NR Transcription [Chen et al., 2004]
Thyroid hormone receptor NR Transcription [Casas et al., 1999;
Fernandez-Vizarra et al., 2008;
Wrutniak et al., 1995]
Glucocorticoid receptor NR Transcription
Apoptosis
[Demonacos et al., 1993;
Psarra and Sekeris 2009]
[Adzic et al., 2009; Talaber et al., 2009;
Sionov et al., 2006]
Nur 77 NR Apoptosis [Wang et al., 2009a;
Li et al., 2000]
Retinoid X Receptor NR Transcription [Casas et al., 2003]
Retinoic Acid Receptor NR Unknown [Berdanier et al., 2001]
Androgen Receptor NR Unknown [Solakidi et al., 2005]
PPARγ2 Coactivator Interacts with
TR
[Casas et al., 2000]
SLIRP NR
repressor
Mitochondrial
mRNA stability
[Baughman et al., 2009]
CREB TF Transcription [Lee et al., 2005;
Ryu et al., 2005;
De Rasmo et al., 2009]
AP-1 TF Transcription [Ogita et al., 2003]
NF-κB TF Transcription
Apoptosis
[Cogswell et al., 2003]
[Zamora et al., 2004]
I-κB Inhibitor of
NF-κB
Unknown [Cogswell et al., 2003]
p53 TF Apoptosis
mtDNA
replication/repair
[Marchenko et al., 2000]
[Yoshida et al., 2003;
Bakhanashvili et al., 2009;
Bakhanashvili et al., 2008]
STAT3 TF Translation [Wegrzyn et al., 2009]
HMGA1 TF DNA binding [Dement et al., 2005]
Wnt13 TF Unknown [Struewing et al., 2006]
*

NR and TF denotes Nuclear Receptor or Transcription Factor, respectively.

HHS Vulnerability Disclosure