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. Author manuscript; available in PMC: 2011 Jan 15.
Published in final edited form as: J Immunol. 2009 Dec 14;184(2):877–885. doi: 10.4049/jimmunol.0902346

Figure 6. MIIG mice mount a normal response to LCMV and clear the infection despite persistent unresponsiveness of macrophages to IFN-γ.

Figure 6

A. MIIG and WT mice were infected with LCMV and bled serially at the indicated time points in order to assess serum IFN-γ levels by ELISA n=6/group B. CD8 and CD4 T cell responses were quantitated at day 7 by intracellular cytokine staining. Percentages shown represent the percent of splenic CD8 or CD4 T cells, respectively, responding to the indicated peptide epitope. C. Quantitation of LCMV viral burden by standard plaque assay at the indicated days after infection. N.D. indicates none detected; pfu indicates plaque forming units. D. Phospho-STAT1 staining of peritoneal macrophages directly ex vivo (without further in vitro stimulation), 7 days after LCMV infection. n=4 animals (except where indicated), with all studies repeated at least twice.

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