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. 2010 Mar 1;49(7):1215–1228. doi: 10.1093/rheumatology/keq031

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© The Author(s) 2010. Published by Oxford University Press on behalf of The British Society for Rheumatology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2 — Structures of anti-TNF agents.

Infliximab is a mouse–human chimeric monoclonal anti-TNF antibody of IgG1 isotype. Adalimumab and golimumab are fully human IgG1 monoclonal anti-TNF antibodies. Etanercept is a fusion protein of the extracellular domain of TNF-R2 and the Fc region of IgG1. Certolizumab pegol is a PEGylated Fab′ fragment of humanized monoclonal anti-TNF antibody.