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A schematic showing the convergence of the PI3K pathway (through mTOR) and the Ras/MAPK pathway (through ER K) on p70s6K and its effect on translation. Note the inhibitory effect of TSC1 and 2, an area not fully explored in gliomagenesis.
Abbreviations: ERK, extracellular signal regulated kinase; MAPK, mitogen-activated protein kinase; mTOR, mammalian target of rapamycin; TSC, tuberous sclerosis complex.
