Table 5.
Common terminology criteria for adverse events v3.0 (CTCAE)109
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 5 | |
|---|---|---|---|---|---|
| Hypertension | Asymptomatic, transient (<24 h) increase by >20 mmHg (diastolic) or to >150/100 if previously within normal limits | Recurrent or persistent (>24 h) or symptomatic increase by >20 mmHg (diastolic) or to >150/100 if previously within normal limits | Requiring more then one drug or more intensive therapy than previously | Life-threatening consequences (hypertensive crisis) | Death |
| Proteinuria | 1+ or 0.15–1.0 g/24 h | 2+ to 3+ or >1.0–3.5 g/24 h | 4+ or >3.5 g/24 h | Nephrotic syndrome | Death |
| Thrombo-embolism | – | DVT or cardiac thrombosis | DVT or thrombosis | Embolic event including PE or life-threatening thrombus | Death |