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. 2010 Jun 14;189(6):981–996. doi: 10.1083/jcb.200910006

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© 2010 Buttitta et al.

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Figure 6. — APC/C activity limits accumulation of E2F-induced cell cycle regulators. GFP-marked clones expressing the indicated cell cycle regulators were generated using hs-FLP tub>Gal4/UAS, tub-Gal80^TS and examined for CycA, CycB, or Gem (A, B, and E–J). Clones negatively marked by CD2, expressing the indicated regulators (C and D) were generated using hs-FLP act>Gal4/UAS and examined for Stg-GFP fusion protein. Cells expressing E2F1–DP in the wing and eye fail to accumulate CycA (A), Stg-GFP (C), Gem (E), and CycB (G) at 40–48 h APF. Cells coexpressing E2F1–DP + Rca1 accumulate CycA (B) and low levels of CycB in the wing (F), as well as Stg-GFP and Gem in the eye (D and H). Cells expressing CycE–Cdk2 accumulate Gem in the eye (I) and CycA in wing (J). (F, I, and J) Yellow outlines indicate clone boundaries. (D) Arrows indicate examples of clones with increased Stg-GFP expression. Bars, 50 µm.