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. 2010 Jun 14;189(6):981–996. doi: 10.1083/jcb.200910006

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© 2010 Buttitta et al.

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Figure 7. — A robust cell cycle control mechanism limits E2F-induced proliferation after cell cycle exit. (A) E2F-dependent transcriptional repression (dotted lines) of targets, including many APC/C components, is established at exit. (B) If aberrant E2F activity occurs, transcriptional activation (dotted arrows) of APC/C components and activators limits the accumulation of key cell cycle targets such as Stg. (C) The resulting high APC/C activity in differentiating cells requires increased CycE to bypass exit, thereby raising the CycE threshold.