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Nitazoxanide (NTZ) increases phosphoryation of protein kinase activated by RNA (PKR) and induces eukaryotic initiation factor 2-apha (eIF2α), which ultimately inhibits translation of viral RNA.
Adapted from Darling JM, Fried MW. Nitazoxanide: beyond parasites toward a novel agent for hepatitis C. Gastroenterology. 2009;136: 760-763.
