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. Author manuscript; available in PMC: 2010 Jun 16.

Published in final edited form as: Open Pain J. 2009;2:30–40. doi: 10.2174/1876386300902010030

Fig. (1) — Time course of the anti-hyperalgesic effects of BQ-123 and BQ-788. Injection of Complete Freund's Adjuvant (CFA, 20 μg/paw, with PBS vehicle) into the plantar hindpaw shortened the latency for paw withdrawal from a noxious thermal stimulus (PWL). (A) Local injection into the same paw of the selective ET_A antagonist, BQ-123 (n=23), at the total doses shown, partially restored the thermal paw withdrawal latency to its baseline value. (B) Local injection of the selective ET_B antagonist, BQ-788 (n=14), reduced CFA-induced thermal hyperalgesia at 45 min to 3 h after adjuvant injection.

* indicates significant difference (P < 0.05) from control, i.e., CFA + vehicle (n=11); ^x significantly different from baseline (pre-CFA) values in the ipsilateral paw (assessed for day 3 only).

Fig. (1) — Time course of the anti-hyperalgesic effects of BQ-123 and BQ-788. Injection of Complete Freund's Adjuvant (CFA, 20 μg/paw, with PBS vehicle) into the plantar hindpaw shortened the latency for paw withdrawal from a noxious thermal stimulus (PWL). (A) Local injection into the same paw of the selective ET_A antagonist, BQ-123 (n=23), at the total doses shown, partially restored the thermal paw withdrawal latency to its baseline value. (B) Local injection of the selective ET_B antagonist, BQ-788 (n=14), reduced CFA-induced thermal hyperalgesia at 45 min to 3 h after adjuvant injection.

* indicates significant difference (P < 0.05) from control, i.e., CFA + vehicle (n=11); ^x significantly different from baseline (pre-CFA) values in the ipsilateral paw (assessed for day 3 only).