Fig. 1.

Body weights of Group VIB phospholipase A₂ (iPLA₂γ) knockout (KO) and wild-type (WT) mice fed Standard Chow (SC) or a Western diet with a high fat content (WD). Male (A) or female (B) iPLA₂γ-KO (squares) and WT (circles) mice were fed SC from the time of weaning until 8 wk of age and thereafter were fed either SC (open symbols) or a WD (closed symbols), as described in experimental procedures and elsewhere (6, 21). Mice were weighed between 0900 and 1100 on a top-loading balance. Mean values ± SE are indicated (n = 72). *Significantly (P < 0.05) greater weight in genotype and diet comparisons; +significantly greater weight only in genotype comparisons.