Fig. 10.

Insulin tolerance tests of iPLA₂γ-KO and WTmice fed SC or WD. Human regular insulin (0.75 U/kg) was administered by ip injection to WT (■) or iPLA₂γ-KO (●) male mice age 6 mo fed SC (A) or WD (B) as in Fig. 1, and blood was collected at baseline (time 0) and at 30, 60, and 120 min after injection to measure glucose concentration, as described in experimental procedures and elsewhere (6, 8, 62). Mean values ± SE are indicated (n = 39). *Significantly (P < 0.05) greater value in genotype and diet comparisons.