Table 1.

Metabolic characteristics of mice maintained on control (10% fat calories) or high-fat (60% fat calories) diets for either 8 or 16 wk

	8 Wk		16 Wk
	Control	High Fat	Control	High Fat
Body weight, g	30.9 ± 0.96	40.5 ± 1.2*	37.4 ± 0.61†	47.4 ± 0.98*†
Fasting glucose, mg/dl	67.7 ± 2.2	101.8 ± 6.9*	72.5 ± 3.0	129.4 ± 13*
Fed total ketones, μmol/l	144.2 ± 12	106.1 ± 6.5*	69.1 ± 3.6†	100.4 ± 4.9*
Fasting total ketones, μmol/l	1,220 ± 104	1,178 ± 119	854 ± 123	1,189 ± 161
Fasting NEFA, mEq/l	0.61 ± 0.036	0.67 ± 0.062	0.81 ± 0.071	1.05 ± 0.065*†
Fasting liver triglycerides, mg/g	80.9 ± 16	110.2 ± 19	94.1 ± 22	201.1 ± 43*†
Fasting insulin, ng/ml	0.40 ± 0.039	1.93 ± 0.33*	1.02 ± 0.078†	3.24 ± 0.71*

Data are means ± SE. NEFA, nonesterified fatty acids.

^*P < 0.05 between control and high-fat groups;

^†P < 0.05 between 8- and 16-wk groups.