TABLE 1.
Allelic frequencies and association analysis of interleukin-23 receptor (IL-23R) and autophagy-related 16-like 1 (ATG16L1) gene variants in British Caucasian inflammatory bowel disease patients and controls
| Variant, single nucleotide polymorphism | Gene | Group | n |
Allele frequency, n (%) |
P (allele) | OR (95%CI) | |
|---|---|---|---|---|---|---|---|
| A | G | ||||||
| rs11209026, c.1142G→A p.R381Q | IL23R | ||||||
| Crohn’s disease | 236 | 13 (2.8) | 459 (97.2) | 0.0006 | 0.37 (0.21–0.67) | ||
| Ulcerative colitis | 160 | 16 (5.0) | 304 (95.0) | 0.18 | 0.69 (0.40–1.18) | ||
| Controls | 813 | 115 (7.10) | 1511 (92.9) | N/A | N/A | ||
| rs2241880, c.1338A→G p.T300A | ATG16L1 | A | G | ||||
| Crohn’s disease | 273 | 229 (41.9) | 317 (58.1) | 0.0017 | 1.36 (1.12–1.66) | ||
| Ulcerative colitis | 188 | 184 (48.9) | 192 (51.1) | 0.81 | 1.03 (0.82–1.29) | ||
| Controls | 834 | 828 (49.6) | 840 (50.4) | N/A | N/A | ||
A Adenine; G Guanine; N/A Not available