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. Author manuscript; available in PMC: 2010 Jun 16.
Published in final edited form as: Hematol Oncol Clin North Am. 2009 Apr;23(2):261–282. doi: 10.1016/j.hoc.2009.01.004

Fig. 1. Hypothetic model for abortive ribosome assembly and p53 activation relevant to DBA.

Fig. 1

Panel A, 60S subunit assembly in healthy individuals; panel B, DBA patients haploinsufficient for RPL35A; panel C, DBA patients haploinsufficient for RPL5. Ribosomal RNAs are shown with twisted lines and ribosomal proteins are shown with circles. Relevant ribosomal proteins are indicted with their numerical designation in the center. The effects of ribosomal proteins on the level or activity of MDM2 and p53 are shown below the assembly pathways. The solid bars indicate that the 5S rRNA-Rpl5-Rpl11 ternary complex may bind more strongly to MDM2, and have a more substantial effect on p53 stabilization that Rpl11 alone (shown with dashed bars).