Table 2.
Diamond Blackfan Anemia (DBA) | Transient Erythroblastopenia of Childhood (TEC) | |
---|---|---|
Pure red cell aplasia | Present | Present |
Age | Younger than 1 year | Older than 1 year |
Inheritance | Sporadic and dominant inheritance. Mutation analysis as available. | Not inherited |
Congenital anomalies | Present | Absent |
Mean Corpuscular Volume (MCV) | Elevated | Normal (may be elevated upon recovery) |
Fetal hemoglobin | Elevated | Normal (may be elevated upon recovery) |
erythrocyte ADA (eADA) activity | Elevated | Normal |
Other cytopenias | May be present | May be present |
All RBC characteristics except eADA activity are helpful only when tested in a reticulocytopenic child. During recovery from TEC, a transient wave of fetal-like erythropoiesis with elevated MCV and fetal hemoglobin may be detected.
Modified from, Dessypris EN, Lipton, JM: Red cell aplasia. In: Wintrobe’s Clinical Hematology, 11th ed., JP, Greer, J, Foerster, JN, Lukens, GM, Rogers, F, Paraskevas, BE, Glader (eds.), Lippincott, Williams & Wilkins, Philadelphia, 2003, pp. 1421–1437