Table 1.
Hemodynamic changes associated with acute ductal constriction in vehicle-treated fetal lambs
| Ductal Constriction |
|||||||
|---|---|---|---|---|---|---|---|
| Preconstriction | 15 Min | 30 Min | 1 H | 2 H | 3 H | 4 H | |
| PAP, mmHg | 54.5 + 3.7 | 66.6 + 8.4* | 65.2 + 7.4* | 68.8 + 7.9* | 68.2 + 8.5* | 64.7 + 10.1* | 65.5 + 8.5* |
| Left pulmonary vascular resistance, mmHg ml−1 min−1kg−1 | 20.3 + 19.6 | 3.3 + 2.5 | 2.3 + 1.2* | 4.3 + 2.7 | 16.3 + 15.2 | 20.7 + 16.6† | 35.5 + 29.9† |
| Left pulmonary blood flow, ml kg−1 min−1 | 7.3 + 6.6 | 21.1 + 9.9* | 25.9 + 10.9* | 17.7 + 12.4 | 8.1 + 8.0† | 4.4 + 4.4† | 3.8 + 5.4† |
| SAP, mmHg | 53.0 + 2.6 | 49.5 + 6.1 | 50.9 + 4.3 | 49.8 + 4.9 | 49.1 + 7.5 | 46.1 + 10.3 | 48.0 + 6.2 |
| SAP-PAP, mmHg | 1.4 + 1.6 | 17.1 + 3.7* | 16.1 + 4.5* | 19.0 + 6.1* | 19.2 + 5.1* | 18.5 + 8.3* | 17.5 + 4.6* |
| PH, units | 7.31 + 0.16 | 7.42 + 0.07 | 7.40 + 0.07 | 7.41 + 0.08 | 7.37 + 0.05 | 7.37 + 0.08 | 7.38 + 0.09 |
| Paco2, Torr | 47.4 + 9.4 | 43.0 + 5.9 | 42.7 + 8.2 | 42.7 + 8.2 | 44.4 + 6.8 | 45.4 + 8.8 | 47.6 + 9.9 |
| Pao2, Torr | 16.7 + 3.1 | 16.0 + 2.0 | 16.3 + 2.5 | 17 + 1.7 | 15.7 + 3.1 | 16 + 4.5 | 15.5 + 2.6 |
Values are means and SD; n = 5 lambs. PAP, pulmonary arterial pressure; SAP, systemic arterial pressure.
*
P < 0.05 vs. preconstriction values.
†
P < 0.05 vs. previous column.