Table 2.
Hemodynamic changes associated with acute ductal constriction in PEG-SOD-treated fetal lambs
| Ductal Constriction |
|||||||
|---|---|---|---|---|---|---|---|
| Preconstriction | 15 Min | 30 Min | 1 H | 2 H | 3 H | 4 H | |
| PAP, mmHg | 49.2 + 7.2 | 60.9 + 8.1* | 60.2 + 10.0* | 61.9 + 5.2* | 61.9 + 7.4* | 57.1 + 6.1 | 55.3 + 10.4 |
| Left pulmonary vascular resistance, mmHg ml−1 min−1kg−1 | 11.6 + 9.5 | 1.9 + 0.5* | 1.7 + 0.8* | 3.7 + 4.0* | 5.2 + 3.9 | 6.2 + 4.8 | 8.1 + 6.3 |
| Left pulmonary blood flow, ml kg−1 min−1 | 6.2 + 4.2 | 32.3 + 9.8* | 39.9 + 21.79* | 32.5 + 26.8* | 18.3 + 13.9† | 16.0 + 14.0† | 12.4 + 10.2† |
| SAP, mmHg | 48.0 + 8.2 | 43.5 + 8.3 | 43.5 + 7.4 | 42.9 + 6.2 | 42.4 + 5.9 | 40.3 + 4.5 | 39.5 + 8.6 |
| PAP-SAP, mmHg | 1.2 + 1.7 | 17.5 + 4.9* | 16.7 + 5.7* | 18.9 + 3.9* | 19.5 + 3.4* | 16.7 + 3.9* | 15.8 + 5.2* |
| PH, units | 7.31 + 0.05 | 7.32 + 0.02 | 7.31 + 0.02 | 7.30 + 0.05 | 7.26 + 0.06 | 7.28 + 0.07 | 7.26 + 0.09 |
| Paco2, Torr | 50.1 + 5.0 | 48.0 + 5.0 | 48.6 + 11.1 | 52.6 + 8.4 | 53.4 + 8.6 | 56.4 + 11.6 | 57.3 + 14.9 |
| Pao2, Torr | 12.2 + 3.4 | 12.8 + 3.6 | 13.1 + 3.6 | 12.8 + 3.9 | 13.0 + 2.73.1 | 16 + 4.5 | 15.5 + 2.6 |
Values are means and SD; n = 7 lambs.
*
P < 0.05 vs. preconstriction values;
†
P < 0.05 vs. previous column.