Table 1.
Inhibitors of substance P-induced IL-8 production
| %Inhibition |
||||||
|---|---|---|---|---|---|---|
| Chemical | Description | SP* | TNF | P Value (TNF) | %Viability | P Value (XTT) |
| Triptolide | Diterpenoid | 99.3 | 100.1 | <0.001 | 105.6 | NS |
| Beclomethasone | Corticosteroid | 93.5 | 77.0 | <0.001 | 97.5 | NS |
| Homoharringtonine | Protein synthesis inhibitor | 93.0 | 98.4 | <0.001 | 89.8 | <0.001 |
| Idarubicin | DNA intercalator | 91.6 | 94.2 | <0.001 | 97.6 | NS |
| Lamivudine | Reverse transcriptase inhibitor | 89.4 | 80.9 | <0.001 | 95.8 | NS |
| Loteprednol | Corticosteroid | 87.3 | 75.6 | <0.001 | 95.5 | NS |
| Desoximetsone | Corticosteroid | 87.0 | 80.8 | <0.001 | 101.2 | NS |
| Tropisetron | Serotonin receptor antagonist | 84.3 | 81.2 | <0.001 | 102.7 | NS |
| 3-[3,5-Dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran | Stimulator of uric acid excretion | 84.2 | 58.9 | <0.001 | 104.1 | NS |
| δ1-Hydrocortisone | Corticosteroid | 82.0 | 74.9 | <0.001 | 105.9 | NS |
| Fluticasone | Corticosteroid | 82.0 | 81.3 | <0.001 | 103.3 | NS |
| Halometasone | Corticosteroid | 81.9 | 80.7 | <0.001 | 103.4 | NS |
| Linezolide | Protein synthesis inhibitor | 78.4 | 70.0 | <0.001 | 97.7 | NS |
| Secnidazole | Nitroimidazole | 77.7 | 63.5 | <0.001 | 102.5 | NS |
| Nitazoxanide | 5-Nitrothiazolyl | 72.0 | 38.9 | <0.001 | 106.5 | <0.05 |
| Cefixime | Cell wall synthesis inhibitor | 69.5 | 45.9 | <0.001 | 92.2 | <0.01 |
| 2H-indol-2-one,1,3-dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl) | Stimulator of neurotransmitter release | 69.1 | 61.8 | <0.001 | 98.4 | NS |
| Doxorubicin | DNA intercalator | 67.6 | 80.4 | <0.001 | 93.4 | <0.05 |
| Corticosterone | Corticosteroid | 67.5 | 42.2 | <0.01 | 99.7 | NS |
| Reichstein's substance S | Corticosteroid | 67.4 | 41.2 | <0.001 | 96.7 | NS |
| Epirubicin | DNA intercalator | 59.1 | 83.1 | <0.001 | 97.5 | NS |
| Megestrol | Reproductive hormone | 55.1 | 52.3 | <0.001 | 100.6 | NS |
| Irbesartan | Angiotensin receptor antagonist | 51.1 | 31.9 | <0.01 | 104.6 | NS |
| Sertraline | Serotonin reuptake inhibitor | 48.5 | 27.7 | <0.01 | 88.9 | <0.001 |
| 10,11-Diol,5,6,6a,7,8,12b-hexahydrobenzo[a]phenanthridine | Dopamine receptor agonist | 44.2 | 53.4 | <0.001 | 100.2 | NS |
| Epigallocatechin gallate | Antioxidant | 37.2 | 16.5 | NS | 101.3 | NS |
| Medroxyprogesterone | Reproductive hormone | 36.3 | 34.7 | <0.001 | 101.3 | NS |
| Nelfinavir | Protease inhibitor | 26.8 | −6.6 | NS | 103.0 | NS |
*
P < 0.001 for all compounds vs. substance P (SP) alone. NS, not significant.