Table 1.
Baseline functional parameters
| Groups | LVSP, mmHg | LVEDP, mmHg | RPP, mmHg/min ×103 | CF, ml/min | Heart Rate, beats/min |
|---|---|---|---|---|---|
| WT (n = 6) | 89 ± 4 | 5 ± 2 | 31 ± 3 | 2.7 ± 0.5 | 385 ± 33 |
| p105−/− (n = 6) | 96 ± 7 | 5 ± 1 | 36 ± 2 | 3 ± 0.3 | 425 ± 27 |
| TSA + WT (n = 5) | 107 ± 11 | 1 ± 1 | 43 ± 7 | 4 ± 0.4 | 392 ± 29 |
| TSA + p105−/− (n = 7) | 90 ± 17 | 4 ± 1 | 39 ± 10 | 3.4 ± 0.7 | 343 ± 19 |
| P values | 0.71 | 0.18 | 0.68 | 0.41 | 0.19 |
Data are means ± SE; n = no. of animals. No significant differences were found between the experimental groups for any of the functional parameters. WT, wild type; LVSP, left ventricular systolic pressure; LVEDP, left ventricular end-diastolic pressure; RPP, rate pressure product; CF, coronary effluent; TSA, trichostatin A.