Fig. 2.
Currents in untranfected and transfected native cardiomyocytes. A: representative current traces from an untransfected cardiomyocyte. Scale = 25 pA by 0.5 s. The voltage-clamp protocol is shown above the currents. Inset a shows inward currents elicited with depolarization (scale = 200 pA by 0.05 s), and inset b shows block of tail current by E4031 (scale = 10 pA by 2 s). The activation relation for peak tail rapidly activating delayed rectifier K+ current is shown at the bottom. B and C: WT hERG-transfected cardiomyocytes. B: block of tail current by E4031. Scale = 50 pA by 2 s. C: a family of current traces and the activation relation for peak tail hERG current (IhERG). Scale = 200 pA by 2 s. Dotted line = 0 pA.